Goals: Bone Health, Antioxidant Properties, Reducing Inflammation, Premenstrual Syndrome (PMS), Connective Tissue, Blood Clotting Factors, Sex Hormones, Beauty, Brain & Focus, Energy & Mood, Gut & Colon, Immune System, Men's Good Aging, Pre-workout, Sleep & Awaken, Stress & Depression, Weight Management, Women's Good Aging
Source Information: Manganese combined with gluconic acid. Good bioavailability. Well-absorbed. Treats manganese deficiencies. Supports bone formation, enzyme activation, blood clotting, antioxidant defense, and metabolic processes. Vitamin C enhances Manganese absorption.
Role: Manganese gluconate is a manganese salt of gluconic acid. When ingested, it dissociates into manganese ions and gluconate in the digestive tract. The manganese ions are absorbed in the small intestine through active transport and diffusion. Once absorbed, manganese is transported to various tissues, including the liver, pancreas, kidneys, and brain, where it acts as a cofactor for several enzymes. Manganese is a cofactor for superoxide dismutase (SOD), an enzyme that helps protect cells from oxidative damage; involved in the formation of bone and connective tissue; plays a role in the metabolism of carbohydrates, amino acids, and cholesterol; is essential for the synthesis of collagen, which is important for wound healing. Manganese, when combined with nutrients like calcium, zinc, and copper, supports bone mineral density. This is particularly important for older adults. It is part of the antioxidant enzyme superoxide dismutase (SOD), which helps combat free radicals. Proper intake of antioxidant nutrients may reduce free radical generation and improve antioxidant status. It helps reduce inflammation and treat inflammatory diseases, such as osteoarthritis and relieves symptoms associated with PMS.
Daily Intake: Normal whole blood concentrations of manganese range from 4 to 15 mcg/L, but they are highly variable and their utility as a status indicator is unclear. As a supplement, the recommended dosage for net manganese gluconate is 2 to 5 milligrams per day for Adults and teenagers. Pregnant individuals have an Adequate Intake (AI) of an upper limit (UL) of 9 mg without healthcare provider supervision.
Supplementation: C₁₂H₂₂MnO₁₄•2H₂O is a manganese salt of gluconic acid. It’s required for the normal functioning of your brain, nervous system, and many of your body’s enzyme systems. While your body stores up to about 20 mg of manganese in your kidneys, liver, pancreas, and bones, you also need to get it from your diet.